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4.6.4 Possible side effects and potential health risks Despite its benefits, RJ may cause allergic reactions, including skin rashes and pruritus, particularly in sensitive individuals (Li et al., 2021)

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TIGAR suppresses EMP and elevates NADPH levels through dual mechanisms: reducing cellular levels of fructose-2,6-bisphosphate (FRU-2,6-P2), a key driver of metabolism towards the EMP, and inhibiting gluconeogenesis